Liquid Chromatography with Mass Spectrometry Detection (LC-MS)


Liquid Chromatography with Mass Spectrometry Detection (LC-MS) is a popular technique at SGS M-Scan. Both Electrospray Ionization (ES-MS) and Atmospheric Pressure Chemical Ionisation (APCI) are available ensuring the maximum range of compounds can be analysed. Typical applications for these techniques include:

  • Pharmaceutical, pharmacokinetics, biochemical and proteomic analysis including the quantitative analysis of drugs and metabolites

  • Separation of mixtures to allow concomitant molecular weight determination

  • ‘Mapping’ of digest mixtures and disulphide bridge analysis

  • Intact molecular weight determination for protein and glycoprotein

  • Identification of impurities and degradants

  • Analysis of polar, high boiling or thermally labile compounds

  • Analysis of detergents used as additives in fuel

  • Analysis of detergents found as carcinogenic environmental contaminants e.g. PFOS from firefighting foams

  • Determination of the effectiveness of oilfield chemicals including corrosion and scale inhibitors

  • Significant increase in specificity over HPLC alone