Headspace GC-MS (HS/GC-MS) is used for the analysis of volatile organic compounds in solid and liquid samples, such as residual solvents and hydrocarbons.
A typical experiment consists of heating a sample containing a solvent in a headspace vial and analyzing the compounds in the headspace by GC-MS. SGS M-Scan’s new TurboMatrix 40 Trap Headspace Sampler coupled to a Perkin Elmer Clarus 500 GC-MS has the capability to heat samples to 210oC. This provides optimized reproducibility and maximized extraction of volatile compounds from the headspace offering improved detection limits. Typical detection limits are in the parts per million (ppm) range.
Headspace GC-MS is used for the following applications:
Unknown impurity ID and quantification
Residual solvent analysis e.g. solvents remaining from the production of pharmaceutical raw materials and finished products
Identification of unknown contaminants and compounds
Analysis of odors and / or non-odorous volatile organic compounds (VOCs) emitted from a wide range of products from food to polymers and pharmaceutical compounds to clothing and toys
Analysis of aerosols, deodorants, perfumes
SGS M-Scan also offers TD GC-MS, another high sensitivity technique for the analysis of VOCs and residual solvents.