Circular Dichroism (CD)

Circular Dichroism - SGS M-Scan’s Wokingham facility is the first in the UK to offer GLP/GMP-compliant Circular Dichroism Analysis (CD), and the first to install Jasco’s latest CD Spectropolarimeter, the J-815, with class leading optical performance versatile for a range of applications, including:

  • Protein folding and conformational studies (secondary structure)

  • DNA/RNA interactions

  • Enzyme kinetics

  • Purity testing of optically active substances

  • Quantitative analysis of pharmaceuticals

  • Natural organic chemistry

  • Biochemistry and macromolecules

  • Rapid scanning (time resolved) experiments

This is a significant enhancement to SGS M-Scan’s Product Characterisation Package, tailored to the ICH Q6B guideline which require Spectroscopic Profiling as part of the assessment of the physicochemical properties of a product. All new biotechnological or biological products need spectroscopic profiling as proof of conformance to gain regulatory approval.

 

Near UV CD 'Fingerprinting' of different batches Near UV CD 'Fingerprinting' of different batches
Near UV CD 'Fingerprinting' of different batches
Far UV Circular Dichroism of different batches Far UV Circular Dichroism of different batches
Far UV Circular Dichroism of different batches
 
 

SGS M-Scan also offers research level NMR for spectroscopic profiling.