Antibody Analysis
SGS M-Scan has unrivalled expertise in biopharmaceutical analysis. As originators of MS Peptide Mapping, together with other mass spectrometry strategies related to protein/glycoprotein characterisation, our customers benefit from our vast experience gained from analysing hundreds of biotechnology products, including antibodies.
Antibody AnalysisSGS M-Scan provides individual analyses, or a full antibody analysis package, tailored to the FDA and ICH guidelines and available to GLP/GMP, including:
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Amino acid sequence analysis, using automated sequencing via Edman degradation and/or MS/MS sequence analysis
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Amino acid composition analysis to provide protein concentration, extinction coefficient and/or molar amino acid ratios
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N-Terminal and C-Terminal amino acid sequence analysis, using automated Edman chemistry and/or mass-spectrometric mapping/sequencing strategies
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Peptide MS Mapping analysis, using digestion and MS strategies
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Disulphide bridge analysis, using MS and MS/MS
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Carbohydrate structure, including monosaccharide composition analysis, oligosaccharide population screening by HPAEC-PAD and MS, linkage analysis and glycosylation site determination
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Determination of intact molecular weight
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Electrophoretic and isoform patterns, including CE
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Liquid chromatographic patterns, including RP-HPLC, SEC and IEX
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Identification of post-translational modifications
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Spectroscopic profiling, using CD
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Identification of product related impurities, including degradation products (deamidation, oxidation, mis-matched S-S bridge forms)
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NMR is available at research level
