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    SGS M-Scan’s laboratories provide analytical services in the area of Life Sciences, including protein analysis, pharmaceutical analysis and bioanalysis. SGS M-Scan also offers a comprehensive portfolio of environmental testing, oil fingerprinting, chemica
  • About us
    • Analytical Excellence
      SGS M-Scan's commitment to excellence derives from unrivalled experience and expertise as a problem-solving contract research laboratory (CRO).
    • Past - Present - Future
      SGS M-Scan Ltd was founded as an independent company in 1979 by Professor Howard R. Morris to provide Analytical Services, Consultancy and Training, particularly in chromatography and mass spectrometry, to the pharmaceutical and chemical industries.
    • Scientific Publications
      SGS M-Scan and its Senior Scientists have established an excellent reputation for major contributions to the research and technical literature, often involving collaborations with Universities and Research Institutes worldwide.
  • Analytical Services & Consultancy
    • Overview
      SGS M-Scan has over 28 years experience of providing analytical services in the areas of
      Life Sciences and Chemistry (Environmental, Oil, Industrial & Forensic).
    • Life Sciences and Pharmaceutical Analysis
      Life Sciences and Pharmaceutical Analysis
      • Characterisation of Biopharmaceuticals
        Mass spectrometry can be used, in conjunction with protein and carbohydrate chemistry, to solve a variety of structural problems.
      • Bioanalysis, Metabolism
        Modern bioanalytical methods for the quantitation of drug compounds, bio molecules (peptides) in biological fluids, or tissues require combined mass spectrometric and chromatographic techniques.
      • Pharmaceutical Analysis
        SGS M-Scan provides a range of analytical services for companies manufacturing small molecule pharmaceutical products.
    • Chemical, Environmental and Forensic
      Chemical, Environmental and Forensic
      • Chemical Analysis
        The analysis of unknown organic compounds associated with manufacturing processes is a particular strength of SGS M-Scan.
      • Environmental Analysis Overview
        SGS M-Scan brings together a range of sophisticated chromatography and mass spectrometry techniques with a team of scientists who have decades of experience in environmental analysis.
      • Forensic Services
        SGS M-Scan's Forensic Services encompass forensic analysis, fire investigation, case review, and training. We have undertaken forensic casework for civil litigation and both criminal prosecution and defence since 1997.
  • Quality
    • Quality Assurance
      SGS M-Scan is committed to maintaining the highest quality analytical services. Our facilities are governed by Standard Operating Procedures (SOPs) with all equipment being appropriately qualified.
    • Regulatory Guidelines
      SGS M-Scan has extensive experience in providing characterisation data for regulatory submissions, stability or product release testing. Analytical services are conducted in accordance with Good Laboratory Practice (GLP) or Good Manufacturing Practice (cG
  • Training
    • Training Courses Overview
      In addition to our analytical services SGS M-Scan provides training through workshops and seminars at a variety of specialist Conferences, Exhibitions and other Events.
    • Course Instructors
      Areas of special expertise in Mass Spectrometry include: protein, carbohydrate and oligonucleotide sequencing; proteomics and post-translational analysis; pharmacokinetics, determination of hydrocarbons and detergents in the environment; forensic science;
    • Current Course Program
      Most Popular SGS M-Scan Courses
      These courses have proved most popular in recent years. Please use the links to download flyers with further details.
    • Key Features of M-Scan Courses
      Tuition from senior staff expert in providing analytical and consultancy services in mass spectrometry and its application to a wide range of studies
    • Training Videos
      Training Videos
      these video excerpts are from a recent event to give you a first impression about what to expect in our training courses.
    • Registration and Payment
      Courses are arranged primarily for our clients and collaborators, but can include others. Anyone interested in attending should contact the Course Organiser (courses@m-scan.com) or their local contact to discuss the possibility of participation in a forth
  • Locations
    SGS M-Scan Worldwide
    • SGS M-Scan Worldwide
      SGS M-Scan Worldwide
    • United Kingdom
      SGS M-Scan Ltd.

      3 Millars Business Centre,
      Fishponds Close,
      Wokingham, Berks. RG41 2TZ
      England, UK.
      Tel: + 44 (0)118 989 6940
      Fax: + 44 (0)118 989 6941

      Email: services.ltd@m-scan.com

    • United States
      SGS M-Scan Inc.

      SGS M-Scan Inc.
      606, Brandywine Parkway,
      West Chester,
      PA 19380 USA.
      Tel.: + 1 (610) 696 8210/8240
      Fax: + 1 (610) 696 8370
      E-mail: services.inc@m-scan.com
    • Switzerland
      SGS M-Scan SA

      12, Chemin des Aulx,
      1228 Plan-les-Ouates,
      Geneva, Switzerland.
      Tel.: + 41 (0)22 794 83 74
      Fax: + 41 (0)22 794 83 55
      Email: services.sa@m-scan.com
    • Germany
      SGS M-Scan GmbH

      Engesserstr. 4a
      D-79108 Freiburg i.Br.
      Germany
      Tel.: +49 (0)761 611 677 60
      Fax: +49 (0)761 611 677 66

      Email: services.de@m-scan.com
    • India
      Bioinnovat Research Services Pvt. Ltd, The Elements, 465 Phase V, Udyog Vihar Industrial Area,
      Gurgaon - 122015 (Haryana),
      India

      Tel: +91 11 41517277 / 41650655
      Fax: +91 11 41354135

      email: guljit@bioinnovat.com
    • Korea
      # 604, Kumgang Building
      93, Garak-dong, Songpa-gu
      Seoul, 138-160, Korea.
      Tel : +82 2 402 3994
      Fax : +82 31 477 9772

      e.mail: jskang@swscience.com
    • Singapore
      Precision Technologies Pte Ltd
      211 Henderson Road #13-02
      Henderson Industrial Park
      Singapore 159552

      Tel: +65 6273 4573
      Fax: +65 6273 8898
      Email: scitech@pretech.com.sg
  • News & More
    News & More
    • Events
      Events
      • News
        News
      • Careers
        The SGS M-Scan group, consisting of four laboratories in United Kingdom, Switzerland, Germany and the USA, was founded in 1979 to provide contract analytical and consulting services utilising mass spectrometry.
    • Life Sciences and Pharmaceutical
      Life Sciences and Pharmaceutical
      • Protein / Peptide Analysis
        Protein / Peptide Analysis
        • Protein Analysis to GMP / GLP
          SGS M-Scan has unrivalled expertise in protein analysis. We are the originators of MS Mapping of biotechnology products, together with other mass spectrometry strategies related to protein / glycoprotein analysis which have become standards worldwide.
        • Amino Acid Analysis (AAA)
          Amino Acid Analysis (AAA) by RP-HPLC is used in protein characterization to analyse peptide or protein concentration, content and molar ratio or, alongside UV spectrophotometry, to gain an extinction coefficient.
        • N-Terminal (Edman) Sequencing
          N-Terminal (amino-terminal) sequencing by automated Edman chemistry, also known as Gas Phase Sequencing (GPS), is used in protein characterisation to determine the amino-terminus of the peptide or protein.
        • C-terminal sequence analysis
          The ability to sequence the C-terminal region of a protein forms a critical part of a protein characterisation package. Identification of the C-terminus and any truncated versions or 'ragged ends' is key in assessing the 'intactness' of a protein.
        • De Novo Protein Sequencing
          De Novo protein sequencing is the process by which the amino acid sequence of a peptide or polypeptide is derived without prior knowledge of the DNA or protein sequence.
        • Peptide Mapping
          Peptide mapping by mass spectrometry (peptide mass fingerprinting) is used in protein characterisation to produce a unique ‘fingerprint’ of an individual protein and to compare this with the theoretical gene-derived amino acid sequence.
        • Disulphide Bridge Analysis
          The number and position of disulfide bridges present plays a crucial role in obtaining a correctly folded product which is crucial to its function.
        • Molecular Weight Analysis (MW)
          For all compound classes, from small organic molecules to intact glycoproteins, the intact molecular weight is a key characteristic in its identity. MS offers accuracy of measurement over a wide molecular weight range with minimal sample consumption.
        • Gel Electrophoresis
          Polyacrylamide Gel Electrophoresis (PAGE) provides a relatively inexpensive yet efficient method for visualising protein mixtures.
        • Capillary Electrophoresis (CE)
          Capillary IsoElectric Focusing (cIEF) delivers superior resolution and reproducibility, compared to conventional Capillary Electrophoresis(CE). cIEF is free solution IsoElectric Focusing (IEF) in a capillary column.
        • Proteomics
          Proteomics is the investigation of gene expression at the protein level. Gene expression and hence cellular protein content can vary both quantitatively and qualitatively according to treatment regimes and/or stress conditions.
        • Post-Translational Modifications (PTMs)
          SGS M-Scan has developed strategies based on mass spectrometry to detect and identify a wide range of co- and post-translational modifications and perhaps most importantly for biopharmaceutical products, glycosylation.
        • Liquid Chromatographic Patterns
          Liquid chromatographic patterns are a requirement of the ICH Q6B guidelines for characterisation and confirmation of biopharmaceuticals in support of new marketing applications.
        • Circular Dichroism (CD)
          SGS M-Scan’s Wokingham facility is the first in the UK to offer GLP/GMP-compliant Circular Dichroism Analysis (CD), and the first to install Jasco’s latest CD Spectropolarimeter, the J-815.
        • Protein NMR
          Nuclear Magnetic Resonance (NMR) is used in protein product characterisation to analyse the chemical structure and composition of biological molecules, including proteins, oligosaccharides, nucleic acids etc.
        • Protein Aggregation
          ICH Topic Q 6 B and the new EMEA Guideline on Development, Production, Characterisation and Specifications for Monoclonal Antibodies recommend analysis of biopharmaceuticals for protein aggregation.
          • SEC-MALS
            AUC and SEC-MALS provide a reliable set of orthogonal data to allow an assessment of aggregation state of a biopolymer product in solution.
          • Analytical Ultracentrifugation (AUC)
            Analytical Ultracentrifugation (AUC) is used to analyse biological molecules in specially designed centrifuges, which can separate a biological molecule into its multimeric states. The sedimentation rate of the molecule is monitored continuously to produc
        • Impurities and Contaminants
          The analysis of product-related and process-related impurities and contaminants in biotech or biological products is a critical aspect during product characterisation.
      • Glycosylation Analysis
        Glycosylation Analysis
        • Glycosylation Analysis Overview
          ICH Q6B states “For glycoproteins, the carbohydrate content (neutral sugars, amino sugars and sialic acids) is determined.
        • Glycosylation Site Analysis
          Glycosylation site analysis is used to determine the population profile of the N-glycans or O-glycans present at each glycosylation site in a glycoprotein. This information can be used in all stages of drug development.
        • Oligosaccharide Population
          Oligosaccharide population analysis is used to determine the overall population profile of the N-glycans or O-glycans present in a glycoprotein. This information can be used at all stages of drug development.
        • Monosaccharide Composition
          Monosaccharide composition analysis is used in the analysis of glycoproteins and carbohydrates to determine the identities and quantities of the various monosaccharides present. This information can be used at all stages of drug development.
        • Linkage Analysis
          Linkage analysis is used in the analysis of glycoproteins and carbohydrates to determine the identities of the various linkages between the monosaccharides present. This information can be used at all stages of drug development.
        • Sialic Acid Analysis
          Sialic acid analysis is used in the analysis of glycoproteins and carbohydrates to determine the identities and quantities of the sialic acid species present. This information can be used at all stages of drug development.
      • Antibody Analysis
        SGS M-Scan provides individual analyses, or a full antibody analysis package, tailored to the FDA and ICH guidelines and available to GLP/GMP.
      • Oligonucleotide Analysis
        Molecular weight measurement of an intact oligonucleotide, up to at least 75-mers in size, can be performed using MALDI-TOF MS, in order to determine its intact mass and provide information on the degree of purity of the sample.
      • Bioanalysis, Metabolism
        SGS M-Scan has extensive experience in the development and validation of methods and utilise an array of cutting edge instrumentation to provide the highest quality bioanalytical service operating to GLP/GMP.
      • Pharmaceutical Analysis
        Pharmaceutical Analysis
        • Pharmaceutical Analysis Overview
          SGS M-Scan provides a range of analytical services for companies manufacturing small molecule pharmaceutical products. Analysis can be performed to GLP/cGMP if required.
        • Residual Solvents in Pharmaceutical Products
          SGS M-Scan offers analytical expertise in the detailed identification and quantification of residual solvents in medicinal products to ICH Topic Q3C.
        • Impurities and Degradants
          ICH Topics Q3A(R)/Q3B ‘Impurities in New Drug Substances’ classifies impurities into organic impurities (process and drug related), inorganic impurities and residual solvents (which are covered in more detail in ICH Topic Q3C).
        • Cleaning Validation
          The CFR Title 21 CFR 211.67 states “Equipment and utensils shall be cleaned, maintained, and sanitised... to prevent malfunctions or contamination that would alter the safety, identity, strength, quality, or purity of the drug product..."
        • PEG, TWEEN and Fatty Acids
          PEG, TWEEN and Fatty Acids
          • Fatty Acid Composition Analysis
            Fatty acid composition analysis is used in the analysis of lipid containing products to determine the identities and quantities of the various fatty acids present.
          • PEG / PPG
            Analysis of PEG and PPG: ICH Topic Q6B (1) provides a uniform set of internationally accepted principles for characterisation of biotechnological products to support new marketing applications. The document suggests that analyses should be performed to pr
          • TWEEN
            ICH Q6B guidelines suggest that in addition to characterising the drug product, there exists a requirement to assess the levels of other components present in the formulation, whether they are product or process related.
      • Extractables & Leachables
        • Extractables
          Multiple extraction solvents with a range of boiling points and polarities, together with multiple extraction techniques selected from reflux, soxhlet extraction and ultrasonication are utilised to maximise the breadth of extraction conditions.
        • Leachables
          Following the identification of extractables, SGS M-Scan can assist with the organisation of appropriate stress testing studies as the precursor to leachables testing.
        • Batch Release Testing (GMP)
          Methods developed for the analysis of the leachables of interest are validated under GMP with the full involvement of SGS M-Scan’s QA Department.
      • SGS’s Clinical & Lab Services
        • SGS’s Clinical & Lab Services Overview
          SGS SGS M-Scan clients can now benefit from the full range of SGS services in Clinical Research and Analytical & QC testing.
        • Clinical Research Services
          SGS offers a complete early phase development package moving products through the pipeline safely and quickly. SGS’s clinical pharmacology facilities are ideally located in Paris, France and Antwerp, Belgium with a total of 172 beds
        • Pharmaceutical QC Testing
          SGS has been offering high quality analytical testing services to the pharmaceutical and biotechnology industries industry for decades. They offer a wide range of quality control testing services to support drug research, registration, and production incl
        • Bioanalytical Services
          As one of Europe's largest bioanalytical service provider, SGS has expertise in mass spectrometry and immunoassays and the capacity to both develop assays de novo and to support large scale routine sample analyses from pre-clinical and clinical studies.
    • Chemical, Environmental and Forensic
      Chemical, Environmental and Forensic
      • Chemical Analysis
        Chemical Analysis
        • Chemical Analysis Services: Overview
          The analysis of unknown organic compounds associated with manufacturing processes is a particular strength of SGS M-Scan. SGS M-Scan has expertise in analysing a wide range of samples from a number of industries.
        • Residual Solvents
          SGS M-Scan offers analytical expertise in the detailed identification and quantification of residual solvents using a proven Thermal Desorption GC-MS method which offers improved specificity over GC alone and improved sensitivity over Headspace GC-MS.
        • Detergents and Surfactants
          SGS M-Scan has extensive experience in the detailed characterisation of surface-active compounds, either singly, in mixtures or in finished products. Appropriate analytical procedures are selected to suit individual projects.
        • Rubber, Plastic and Polymers
          • Rubber, Plastic and Polymers
            SGS M-Scan's experience includes the analysis of natural and synthetic polymers and plastics, extractables and leachables for the pharmaceutical industry, and alkoxylated additives in gasoline.
          • WEEE and RoHS Analysis
            SGS M-Scan has developed mass spectrometry methods for the analysis of brominated flame retardants in plastics and other organic compounds prohibited under the EU’s WEEE and the Directive on the RoHS.
        • Food, Oils and Fats
          SGS M-Scan has investigated allegations from consumers, manufacturers, suppliers, distributors and insurance companies that fruit, spices, oils and even processed convenience food have unpleasant taints and/or odours.

        • Allergens
          SGS M-Scan has the capability to identify and quantify allergenic components in formulated products and blends as well as the airborne environment.

        • Oil and Petrochemical Analysis
          • Oil and Petrochemical Analysis
            SGS M-Scan’s chromatography mass spectrometry services are utilised extensively in the oil industry, ranging from exploration and production, through to final refined and formulated products.
          • Analysis of Fuels
            SGS M-Scan has 12 years experience in compliance testing and ‘fingerprinting’ of racing fuels and is the lead laboratory in the FIA Formula 1 fuel testing programme.
          • Oil Fingerprinting and Oil Spills
            SGS M-Scan specialises in the forensic use of capillary GC and GC-MS to "fingerprint" spilled oils, and provides a specific service in this field to oil companies, insurers, tanker owners and port authorities
        • Volatile Organic Compounds and Odours
          SGS M-Scan has unrivalled expertise in the analysis of smells and non odorous volatile organic compounds (VOC) using techniques like Headspace GC-MS and the more sensitive Thermal Desorption GC/MS (TD GC-MS)
      • Environmental Analysis
        Environmental Analysis
        • Environmental Analysis Services: Overview
          SGS M-Scan has methods for the analysis of air, water (marine and freshwater) and contaminated land samples
        • Oil Fingerprinting and Oil Spills
          SGS M-Scan specialises in the use of capillary GC and GC-MS to "fingerprint" spilled oils, using biological markers and provides a specific service in this field to oil companies, insurers, tanker owners and port authorities
        • Odours
          • Odours
            SGS M-Scan has unrivalled expertise in the analysis of odours and Volatile Organic Compounds (VOC) using Thermal Desorption GC/MS (TD GC-MS).
          • Indoor Air Quality
            SGS M-Scan offers both Thermal Desorption GC-MS (TD GC-MS) for the screening of volatile organic compounds (VOCs) and the identification of nuisance odours, as well as Liquid Chromatography (LC-UV) for the analysis of aldehydes, including formaldehyde.
          • Outdoor Air Quality
            Thermal Desorption GC-MS is ideal for the analysis of odours and/or non odorous volatile organic compounds (VOC) found in the outdoor environment.
          • Vehicle Air Quality
            SGS M-Scan’s Thermal Desorption GC-MS (TD GC-MS) techniques have been widely used for the analysis of Vehicle Indoor Air Quality (VIAQ), aircraft cabin air and marine cargo contamination..
        • Contaminated Land
          Contaminants can be extracted from soil, ground water or collected as free product floating on top of ground water.
        • Seawater and Sediments
          SGS M-Scan offers an extensive range of techniques for hydrocarbon analysis in the marine environment. These include monitoring baseline hydrocarbon levels pre drilling, post drilling or abandonment surveys of cutting piles and oil fingerprinting
        • Produced Water
          SGS M-Scan has expertise in the analysis of produced waters and aqueous discharges including volatiles (particularly benzene, toluene, ethylbenzene, xylenes ((BTEX), low boiling saturates and solvents)
        • PFOS Analysis
          The SGS M-Scan laboratory first analysed PFOS in environmental samples in the mid 1990s and has analysed thousands of samples over the intervening period.
        • Environmental Surveys
          SGS M-Scan undertakes a wide range of environmental surveys from the collection of marine, river and lake samples to boundary fence and plant emissions monitoring.
      • Forensic Services
        • Forensic Services Overview
          SGS M-Scan's Forensic Services encompass forensic analysis, fire investigation, case review, and training. We have undertaken forensic casework for civil litigation and both criminal prosecution and defence since 1997.

        • Forensic Expertise & Experience
          SGS M-Scan’s scientists have a wide range of specialist expertise which means they are considered experts within their field. They have provided expert testimony (verbal and written) to many courts throughout the UK.
        • Collaborations
          SGS M-Scan has strong links with Gardiner Associates Ltd (www.gardinerassociates.com), the UK’s leading provider of fire investigation training, and also with First Forensic Ltd (www.firstforensic.co.uk).
        • Criminal Prosecution
          Our forensic scientists can provide expert advice ranging from exhibit analysis and fire/explosion scene attendance to case review and general consultancy.
        • Criminal Defence
          Given the experience and expertise of SGS M-Scan’s forensic scientists, they can provide expert advice to the defence for prosecutions involving incidents of fire/explosion (e.g. arson, and associated “endangerment of life” and “recklessness” charges) and
        • Case Review
          Due to the experience and expertise of our scientists, SGS M-Scan is able to review active and cold cases in the context of criminal investigations (prosecution and defence) or civil litigation proceedings. We are able to review fire/explosion casework as
        • Forensic Training
          Our forensic scientists can provide training.
        • Fire Investigation
          With over 10 years’ experience, our scientists can attend scenes to establish the origin and cause of any incident of fire or explosion.
        • Fire Debris Analysis
          SGS M-Scan can analyse any type of fire debris for the presence of “accelerants”. The identification of product types is made with reference to our own extensive database of reference materials, and also using authoritative peer-reviewed publications.

        • Characterisation of Liquids
          Given SGS M-Scan’s expertise in the analysis of petrochemicals, we are accustomed to undertaking the detailed characterisation of liquids (or semi-liquids). These analyses can be used to quite simply determine the identity of an unknown product and also t
        • Petrol Branding
          SGS M-Scan developed petrol branding in 1997 in response to a case involving the death of 3 generations of a family whose house was petrol bombed. Over the past 10 years, many hundreds of petrol samples have been analysed and differentiated by means of th
        • Fuel Correlation
          Liquid and semi-liquid distillate products (e.g. petrol, kerosene, and diesel) can be analysed and easily compared in order to establish a common source (i.e. it can be determined whether or not two or more products are indistinguishable).
        • Lachrymator Analysis
          We can analyse lachrymator residues from aerosols or on garments that have been sprayed with a “defence gas spray”. Our analysis involves a microscopic examination of any garments followed by analysis for lachrymator residues.

        • Consultancy and Expert Witness
          SGS M-Scan’s team of scientists offer interpretative services and second opinions on data obtained by third parties in the forensic, environmental and chemical analysis fields.
    • Analytical Techniques
      Analytical Techniques
      • Liquid Chromatography - LC
        Liquid Chromatography - LC
        • HPLC
          High pressure liquid chromatography (HPLC) is a liquid chromatographic technique in which the sample is forced through the column under high pressure.
        • SEC
          Size exclusion chromatography (SEC) is a liquid chromatographic technique in which particles are separated based on their size, or hydrodynamic volume. Particles of different size elute at different rates through the column, the larger eluting first.
        • IEX / IEC
          Ion Exchange Chromatography (IEX / IEC) - in this technique proteins including antibodies, small nucleotides and amino acids may be separated depending on their net charge.
        • HPAEC-PAD
          HPAEC-PAD - High Performance Anion Exchange Chromatography with Pulsed Amperometric Detection separates carbohydrates via specific interactions between the hydroxyl groups of the glycan and the stationary phase of the column at high pH.
        • LC-MS
          LC-MS is a popular technique at SGS M-Scan. Both ES-MS and APCI are available ensuring the maximum range of compounds can be analyzed.
        • LC-MS/MS
          Liquid Chromatography with Tandem Mass Spectrometry Detection (LC-MS/MS) is used extensively by SGS M-Scan for pharmaceutical, biochemical and other analytical areas. SGS M-Scan has a range of ‘Triple Quad’, ‘Q-TOF’ and ‘Q-Trap’ instruments available.
        • LC-DAD and LC-DAD/MS
          Diode array detection is a multi-wavelength detection system that enables the simultaneous collection of absorption data from a range of UV and visible (UV/vis) wavelengths for the analysis of dyes and chromophores.
      • Mass Spectrometry - MS
        Mass Spectrometry - MS
        • LC-MS
          Liquid Chromatography with Mass Spectrometry Detection (LC-MS) is a popular technique at SGS M-Scan. Both Electrospray Ionisation (ES-MS) and Atmospheric Pressure Chemical Ionisation (APCI) are available ensuring the maximum range of compounds can be anal
        • LC-MS/MS
          Liquid Chromatography with Tandem Mass Spectrometry Detection (LC-MS/MS) is used extensively by SGS M-Scan for pharmaceutical, biochemical and other analytical areas. SGS M-Scan has a range of ‘Triple Quad’, ‘Q-TOF’ and ‘Q-Trap’ instruments available.
        • ES-MS
          Electrospray Ionisation Mass Spectrometry (ES-MS) is a method in which a stream of liquid, containing one or more analytes, is injected via a capillary into the atmospheric pressure ion source of a mass spectrometer.
        • ES-MS/MS
          ES-MS is a technique which, in most cases, provides a molecular ion species with little or no fragmentation, due to the low energy imparted during ionization.
        • MALDI-TOF MS
          MALDI-TOF MS, Matrix Assisted Laser Desorption Ionisation-Time Of Flight MS, involves mixing the sample with a matrix, which is then coated on to a plate or probe, and subjected to a collimated focused laser beam, causing ionisation and desorption.
        • FAB-MS
          Fast Atom Bombardment provides an efficient means of analysing polar, ionic, thermally labile and high molecular weight compounds not amenable to analysis by Electron Impact or Chemical Ionisation.
        • EGA-MS
          SGS M-Scan uses a Frontier Laboratories PY2020D double-shot pyrolyser coupled to a Shimadzu QP2010 GC-MS for the analysis of solid samples by Evolved Gas Analysis Mass Spectrometry, EGA-MS.
        • GC-MS
          Gas Chromatography-Mass Spectrometry (GC-MS) is used by SGS M-Scan for a wide range of analyses. The combination of these two powerful techniques and the extensive library of data available to assist in the identification of unknown species.
        • Headspace GC-MS
          While not as sensitive as Thermal Desorption GC-MS, Headspace GC/MS is appropriate for the analysis of very light volatiles which easily partition into the head space gas volume above a liquid or solid sample.
        • TD GC-MS
          The inherent sensitivity of chromatography and mass spectrometry makes the combined techniques ideal for the analysis of smells, odours and/or non odorous VOCs emitted from a wide range of products from food to polymers and pharmaceutical compounds.
        • Pyrolysis GC-MS
          SGS M-Scan has two Pyrolysis GC-MS systems, the Frontier Laboratories PY2020D double-shot pyrolyser coupled to a Shimadzu QP2010 GC-MS and the Pyrola 2000 pyrolyser coupled to a PE Turbomass Gold GC-MS.
      • Gas Chromatography - GC
        Gas Chromatography - GC
        • GC-MS
          Gas Chromatography-Mass Spectrometry (GC-MS) is used by SGS M-Scan for a wide range of analyses. The combination of these two powerful techniques and the extensive library of data available to assist in the identification of unknown species.
        • Headspace GC-MS
          While not as sensitive as Thermal Desorption GC-MS, Headspace GC/MS is appropriate for the analysis of very light volatiles which easily partition into the head space gas volume above a liquid or solid sample.
        • TD GC-MS
          The inherent sensitivity of chromatography and mass spectrometry makes the combined techniques ideal for the analysis of smells, odours and/or non odorous VOCs emitted from a wide range of products from food to polymers and pharmaceutical compounds.
        • Pyrolysis GC-MS
          SGS M-Scan has two Pyrolysis GC-MS systems, the Frontier Laboratories PY2020D double-shot pyrolyser coupled to a Shimadzu QP2010 GC-MS and the Pyrola 2000 pyrolyser coupled to a PE Turbomass Gold GC-MS.
        • GC-FID/ECD
          There are several types of detector available for GC instruments of which the most common are Flame Ionisation Detectors (FID), Electrochemical Detectors (ECD) and Mass Spectrometry (MS).
      • Other Techniques
        Other Techniques
        • Capillary Electrophoresis (CE)
          Capillary IsoElectric Focusing (cIEF) delivers superior resolution and reproducibility, compared to conventional Capillary Electrophoresis(CE). cIEF is free solution IsoElectric Focusing (IEF) in a capillary column.
        • TOC
          Total Organic Carbon (TOC) is used in the pharmaceutical/biopharmaceutical industry as a quick, accurate and inexpensive screening protocol for contamination validation of small molecule drugs, peptides, proteins, and cleaning detergents.
        • Circular Dichroism (CD)
          Circular Dichroism - SGS M-Scan’s Wokingham facility is the first in the UK to offer GLP/GMP-compliant Circular Dichroism Analysis (CD).
        • Protein NMR
          Nuclear Magnetic Resonance (NMR) is used in protein product characterisation to analyse the chemical structure and composition of biological molecules.
        • Analytical Ultracentrifugation (AUC)
          Analytical Ultracentrifugation (AUC) is used to analyse biological molecules in specially designed centrifuges, which can separate a biological molecule into its multimeric states.
      • Equipment List
        Equipment List
    • Contact
      Contact